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Guanglin He's Photo

Guanglin He

Department/Institution：West China Institute of Rare Diseases
Research Field：Ancient genomics, molecular anthropology

He Guanglin, Associate Research Fellow at the Center for Archaeological Sciences, Sichuan University / Rare Diseases Institute, West China Hospital of Sichuan University. He is the Vice Chairman of the Sichuan Provincial Special Committee for Big Data Research in Otolaryngology, a Council Member of the Sichuan Society of Genetics, and the Vice Chairman of the Third Youth Committee of the Medical Genetics Professional Committee, Sichuan Medical Association. His research interests include forensic genomics, paleogenomics, and evolutionary genomics. He serves as an Associate Editor or Editorial Board Member for six SCI journals, including *BMC Biology* and *BMC Genomic Data*. He received his Ph.D. from Sichuan University in 2020. From 2020 to 2022, he conducted postdoctoral research at the School of Life Sciences, Xiamen University, and Nanyang Technological University, Singapore, focusing on paleogenomics and population evolutionary genomics. He has published over 70 SCI papers as the first or corresponding author in journals such as *Science Advances*, *Molecular Biology and Evolution*, *Genome Biology*, *Genomics, Proteomics & Bioinformatics*, *Science China Life Sciences*, *BMC Biology*, *Journal of Genetics and Genomics*, *European Journal of Human Genetics*, and *Forensic Science International: Genetics*. He has also co-authored several papers in SCI journals like *Nature* and *Science Bulletin*. He has led multiple projects funded by the National Natural Science Foundation of China and the National Social Science Fund, and has been listed among the world's top 2% scientists for two consecutive years.

Research Directions

1) Precision Identification in Forensic Genomics and Genomic Diversity of Chinese Populations: Utilizing the large-scale genomic cohort established by the "10K Chinese People Genomic Diversity Project" (10K_CPGDP), this research systematically analyzes the genetic structural characteristics and complex evolutionary history of Chinese populations. This includes patterns of population genetic differentiation and historical migration dynamics, the co-evolutionary relationships between gene flow and cultural/linguistic diversity, and the construction of a high-precision genetic variation reference map for Chinese populations to provide foundational data support for individual identification in forensic genomics and disease association studies in medical genomics.

2) Structural Evolution of the Y Chromosome Genome and its Translational Research in Forensic Genomics: Based on the sample resources of the "YanHuang Cohort" (YHC) and integrating second- and third-generation sequencing technologies, this research comprehensively analyzes the characteristics and evolutionary patterns of structural variations on the Y chromosome. It also involves reconstructing a high-resolution phylogenetic tree of paternal genetic pedigrees for East Asian populations and developing a high-sensitivity detection system for Y-chromosome genetic markers applicable to forensic practice.

3) Population Genetics of Mitochondrial Genomes and its Medical Applications: Using large-scale mitochondrial genome data from Chinese populations, this research develops bioinformatics tools for the quantitative analysis of mitochondrial DNA heteroplasmy and the precise identification of nuclear mitochondrial pseudogenes (NUMTs). It also aims to map the mitochondrial genetic diversity of Chinese populations and establish a medical reference database for the association between mitochondrial mutations and diseases.

4) Host-Pathogen Co-evolution and the Evolutionary Mechanisms of the Immune System: By integrating genomic data from modern populations and ancient genomes, this research analyzes the genetic mechanisms of human adaptive evolution driven by pathogen selective pressure. It elucidates the impact of archaic human gene introgression events on the formation of the innate immune genetic network in modern populations and reveals the evolutionary history and functional significance of immune-related genes.

Selected Publications

1. Yuguo Huang, Mengge Wang, Zhiyong Wang, Xiaojun Liu, Yuhang Feng, Jie Zhong, Hailin Huang, Jia Geng, Ting Tang, Chao Liu, Yu Lu, Jing Cheng, Fengxiao Bu, Guanglin He, Huijun. Yuan, Short tandem repeats in populations of the Qinghai-Tibet Plateau and adjacent regions provide insights into high-altitude adaptation. Science advances (2025).

2. Guanglin He, J. Chen, S. Duan, Q. Yang, B. Li, L. Luo, J. Zhong, Q. Sun, F. Bu, R. Tang, H. Lu, K. C. Consortium, H. Yuan, H. Yuan, C. Liu, Mengge Wang, Largest-Scale Genomic Resource Reconstructing the Genetic Origin, Population Structure, and Biological Adaptations of the Hui People. Mol Biol Evol (2025).

3. Mengge Wang, Y. Huang, K. Liu, Z. Wang, M. Zhang, H. Yuan, S. Duan, L. Wei, H. Yao, Q. Sun, J. Zhong, R. Tang, J. Chen, Y. Sun, X. Li, H. Su, Q. Yang, L. Hu, L. Yun, J. Yang, S. Nie, Y. Cai, J. Yan, K. Zhou, C. Wang, K. C. Consortium, B. Zhu, C. Liu, Guanglin He, Multiple Human Population Movements and Cultural Dispersal Events Shaped the Landscape of Chinese Paternal Heritage. Mol Biol Evol 41 (2024).

4. Guanglin He, H. Yao, S. Duan, L. Luo, Q. Sun, R. Tang, J. Chen, Z. Wang, Y. Sun, X. Li, L. Hu, L. Yun, J. Yang, J. Yan, S. Nie, Y. Zhu, K. C. Consortium, C. C. Wang, B. Liu, L. Hu, C. Liu, Mengge Wang, Pilot work of the 10K Chinese People Genomic Diversity Project along the Silk Road suggests a complex east-west admixture landscape and biological adaptations. Sci China Life Sci 68, 914-933 (2025).(ESI Highly Cited Paper)

5. L. Luo, Mengge Wang, Y. Liu, J. Li, F. Bu, H. Yuan, R. Tang, C. Liu, Guanglin He, Sequencing and characterizing human mitochondrial genomes in the biobank-based genomic research paradigm. Sci China Life Sci 68, 1610-1625 (2025).(ESI Highly Cited Paper)

6. Z. Wang, K. Liu, H. Yuan, S. Duan, Y. Liu, L. Luo, X. Jiang, S. Chen, L. Wei, R. Tang, L. Hu, J. Chen, X. Li, Q. Yang, Y. Sun, Q. Sun, Y. Huang, H. Su, J. Zhong, H. Yao, L. Yun, J. Li, J. Yang, Y. Cai, H. Deng, J. Yan, B. Zhu, K. C. Consortium, K. Zhou, S. Nie, C. Liu, Mengge Wang, Guanglin He, YanHuang Paternal Genomic Resource Suggested A Weakly-Differentiated Multi-Source Admixture Model for the Formation of Han's Founding Ancestral Lineages. Genomics, Proteomics & Bioinformatics (2025).

7. Q. Yang, Y. Sun, S. Duan, S. Nie, C. Liu, H. Deng, Mengge Wang, Guanglin He, High-quality Population-specific Haplotype-resolved Reference Panel in the Genomic and Pangenomic Eras. Genomics, Proteomics & Bioinformatics(2025).

8. Y. Sun, Mengge Wang, Q. Sun, Y. Liu, S. Duan, Z. Wang, Y. Zhou, J. Zhong, Y. Huang, X. Huang, Q. Yang, X. Li, H. Su, Y. Cai, X. Jiang, J. Chen, J. Yan, S. Nie, L. Hu, J. Yang, R. Tang, C. C. Wang, C. Liu, X. Deng, L. Yun, Guanglin He, Distinguished biological adaptation architecture aggravated population differentiation of Tibeto-Burman-speaking people. J Genet Genomics 51, 517-530 (2024).

9. Mengge Wang, H. Chen, L. Luo, Y. Huang, S. Duan, H. Yuan, R. Tang, C. Liu, Guanglin He, Forensic investigative genetic genealogy: expanding pedigree tracing and genetic inquiry in the genomic era. J Genet Genomics 52, 460-472 (2025).(ESI Highly Cited Paper)

10. Mengge Wang, Q. Sun, Y. Feng, L. H. Wei, K. Liu, L. Luo, Y. Huang, K. Zhou, H. Yuan, H. Lv, Y. Lu, J. Cheng, S. Wen, C. C. Wang, R. Tang, F. Bu, C. Liu, H. Yuan, Z. Wang, Guanglin He, Paleolithic divergence and multiple Neolithic expansions of ancestral nomadic emperor-related paternal lineages. J Genet Genomics 52, 502-512 (2025).

11. Guanglin He, P. Wang, J. Chen, Y. Liu, Y. Sun, R. Hu, S. Duan, Q. Sun, R. Tang, J. Yang, Z. Wang, L. Yun, L. Hu, J. Yan, S. Nie, L. Wei, C. Liu, Mengge Wang, Differentiated genomic footprints suggest isolation and long-distance migration of Hmong-Mien populations. BMC Biol 22, 18 (2024).

12. Q. Sun, Mengge Wang, T. Lu, S. Duan, Y. Liu, J. Chen, Z. Wang, Y. Sun, X. Li, S. Wang, L. Lu, L. Hu, L. Yun, J. Yang, J. Yan, S. Nie, Y. Zhu, G. Chen, C. C. Wang, C. Liu, Guanglin He, R. Tang, Differentiated adaptative genetic architecture and language-related demographical history in South China inferred from 619 genomes from 56 populations. BMC Biol 22, 55 (2024).

13. Mengge Wang, S. Duan, Q. Sun, K. Liu, Y. Liu, Z. Wang, X. Li, L. Wei, Y. Liu, S. Nie, K. Zhou, K. C. consortium, Y. Ma, H. Yuan, B. Liu, L. Hu, C. Liu, Guanglin He, YHSeqY3000 panel captures all founding lineages in the Chinese paternal genomic diversity database. BMC Biol 23, 18 (2025).

14. Guanglin He, Z. Wang, J. Guo, Mengge Wang, X. Zou, R. Tang, J. Liu, H. Zhang, Y. Li, R. Hu, L. H. Wei, G. Chen, C. C. Wang, Y. Hou, Inferring the population history of Tai-Kadai-speaking people and southernmost Han Chinese on Hainan Island by genome-wide array genotyping. Eur J Hum Genet 28, 1111-1123 (2020).

Full lists of all publications:

Research Gate: https://www.researchgate.net/profile/Guanglin-He-heguanglin-2/research

Google: https://scholar.google.com/citations?user=FLRq3GEAAAAJ&hl=zh-TW&oi=sra

Contact Information

Lab Website: https://helabforensics.com/index.html